I have succeed install the following
Nginx:80 -> Varnish:6081 -> Apache:8080
but the problem is when add new domain the VirtualHost in webuzoVH.conf keep rewritten to the Port 80, how to override VirtualHost and NameVirtualHost in webuzoVH.conf to always write the Port to 8080 (apache).
if anyone interested i will post all config file, the interesting thing is no need to create/rewrite Nginx virtualhost file every you add new domain/subdomain on webuzo control panel and here are the demo sites: www.ypal.biz and i.ypal.biz