Certainly. I installed Wordpress in order to build a new theme for my webcomic and then port over. WHen installing WP, it showed half the images missing. I then imported my current build over just to make sure that it wasn't just something in WP, and then found that, again, half the images were missing.
It isn't an issue on WP, as this doesn't seem to be affecting my online build at my webhost, but only the one on my system. I've done numerous virus scans (all come up negative) in case I somehow picked up a virus but to date nothing shows up an issue.
Lastly, I brought it up with the folks whose plugins I use and no problems have been reported there either, so this is the latest avenue I'm investigating.